王依慰

医学博士，拥有多家大型三甲医院的临床经验，擅长跨学科协作与方案整合。具备扎实的跨学科沟通与临床研究能力。主持国家自然科学基金，成功转型为临床研究者。熟悉GCP流程，积累了丰富的项目管理、数据监控与安全性事件管理经验。具备各级学术活动组织策划经验。参与科室药械引进，优化应用流程，确保临床实践高效落地。肾小乐公众号共同创办人，负责内容创作与运营，助力平台成为领先的专科平台，提升医学科普与科研信息的传播。

1.国家自然科学基金，82001474，基于Mfg-e8-外泌体的小胶质细胞ERS精准调控在老

年POCD治疗中的应用及机制研究，2021.01.01-2023.12.31, 已结题，主持。

2.江苏省普通高校研究生科研创新计划项目，KYCX17_1250POCD炎症学说中效应肥

大细胞的来源2017.01-2018.05已结题，主持。

1.Wang Y, Hu L, Zhou D, Chen X, Zhou L. Association of Urinary Biomarkers of Renal Tubular Injury with Cognitive Dysfunction in Older Patients with Chronic Kidney Disease: A Cross-Sectional Observational Study. Brain Sciences 2023, 13(4):551.（IF=3.33）

2.Wang Y, Wang L, Yuan S, Zhang Y, Zhang X, Zhou L. Postoperative Cognitive Dysfunction and Alzheimer's Disease: A Transcriptome-Based Comparison of Animal Models. Frontiers in Aging Neuroscience 2022;14: 900350.（IF=5.7）

3.Wang Y#, Sha H#, Zhou L#, Chen Y, Zhou Q, Dong H, Qian Y*. The Mast Cell Is an Early Activator of Lipopolysaccharide-Induced Neuroinflammation and Blood-Brain Barrier Dysfunction in the Hippocampus. Mediators of Inflammation 2020; 8098439. (IF=4.53)

4. Wang Y#, Chen Y#, Zhou Q, Xu J, Qian Q, Ni P, Qian Y*. Mild Endoplasmic Reticulum Stress Protects Against Lipopolysaccharide-Induced Astrocytic Activation and Blood-Brain Barrier Hyperpermeability. Frontiers in Cellular Neuroscience 2018;12: 222. (IF=6.15)

5. Wang Y#, Zhou Q#, Zhang X#, Qian Q, Xu J, Ni P, Qian Y*. Mild Endoplasmic Reticulum Stress Ameliorates Lipopolysaccharide-Induced Neuroinflammation and Cognitive Impairment via Regulation of Microglial Polarization. Journal of Neuroinflammation 2017;14(1):233. (IF=9.6)

6. Wang Y#, Zhang X#, Chen C, Liu Q, Xu J, Qian Q, Li W*, Qian Y*. Protective Effects of Garcinol Against Neuropathic Pain - Evidence From in Vivo and in Vitro Studies. Neuroscience Letters 2017;647: 85-90. (IF=3.2)

7. Qian Q#, Zhang X#, Wang Y#共同一作, Xu J , Dong H, Li N, Qian Y*, Gui B*. Pro-inflammatory Role of High-Mobility Group box-1 on Brain Mast Cells via the RAGE/NF-κB Pathway. Journal of Neurochemistry 2019;151(5):595-607. (IF=5.55)

8. Zhou Q#, Wang Y#共同一作, Ni P, Chen Y, Dong H, Qian Y*. Effect of Tryptase on Mouse Brain Microvascular Endothelial Cells via Protease- Activated Receptor 2. Journal of Neuroinflammation 2018;15(1):248. (IF=9.6)

9. Ni P#, Dong H#, Wang Y#共同一作, Zhou Q, Xu M, Qian Y, Sun J*. IL-17A Contributes to Perioperative Neurocognitive Disorders Through Blood-Brain Barrier Disruption in Aged Mice. Journal of neuroinflammation 2018;15(1):332. (IF=9.6)

10.Bhuiyan Piplu, Wang Y, Sha H, Dong H, Qian Y, Neuroimmune connections between corticotropin-releasing hormone and mast cells: novel strategies for the treatment of neurodegenerative diseases. Neural Regeneration Research 2021;16(11):2184-2197. (IF=6.06)

11.Chen Y, Sha H, Wang Y, Zhou Q, Bhuiyan Piplu, Li N, Qian Y and Dong H, Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats. Journal of Neuroinflammation 2020;17(1):217.(IF=9.6)

12. 王依慰, 陈春龙, 支亦博, 章洁, 李伟彦. 瑞芬太尼与舒芬太尼麻醉对全麻病人苏醒质量影响的系统分析.医学研究生学报,2016,29(2): 170-177.

13. 王依慰,刘清珍,陈春龙,支亦博,章洁,李伟彦.白藜芦醇通过降低NF-κB p65乙酰化缓解大鼠神经病理性疼痛.中国药理学通报,2016,32(1): 89-93.

14. 王依慰，李伟彦. 沉默信息调节因子1去乙酰化对核因子κB 功能的影响.中国医药导报,2015,12(16): 454-458.

15. 王依慰，李伟彦. P38促分裂原活化蛋白激酶在神经病理性疼痛中的作用.中国临床神经科学,2015,23(4): 56-61.

• 麻醉学中级证书、临床执业医师证书、住院医师规范化培训证书、GCP证书。
• 英语CET6、计算机三级、普通话证书。
• 事业单位工作人员嘉奖、住院医师高级师资培训证书。