Jua Kim

Main research interests include biomaterials, metals, biodegradable metals, precision/personalized biomaterials, bioactive materials, in vitro and in vivo testing, corrosion, degradation, electrochemical reactions, protein adsorption, immunomodulation, inflammation, material-cell interaction, bone and bone diseases like osteoporosis and osteosarcoma, bone regeneration, biocompatibility, and oxidative stress.

Teaching Assistant, Course: Biomaterials and Medical Devices, Syracuse University (Spring 2016 and Spring 2012)

• This class included undergraduate and graduate students majoring in biomedical engineering and biotechnology (60-80 students per class).
• Teaching this course required a good understanding of biomaterials used in medical devices and implants, biological systems involved with medical devices, and the design and performance of biomaterials-based medical devices.

Lab Instructor, Course: Quantitative Physiology , Syracuse University (Spring 2013)

• This class involved teaching undergraduate (junior-senior level) students majoring in biomedical engineering (20-30 students per class).
• Teaching this course required a good understanding of mammalian physiology from an engineering perspective, where each of the major systems of the body is addressed with an emphasis on electrical, mechanical, and thermodynamic principles. The lab section had to be taught independently and required extensive use of data acquisition software LabVIEW and MATLAB, as well as animal handling and dissection (e.g., frogs, worms, squid, rats).
• Some examples of lab course involved dissecting a frog to retrieve a leg muscle and then stimulating the sciatic nerve to show how the nerve activates the gastrocnemius muscle. MATLAB was used to model Windkessel model to study the fluid behavior in the cardiovascular system in different cardiac conditions (e.g., arrythmia, exercise, obesity, etc.). This lab also involved handling live rats to measure its frequency and tidal volume of respiration when various mixtures of respiratory gases were delivered.

Lab Instructor, Course: Bioengineering Laboratory , Syracuse University (Fall 2012)

• This class involved teaching undergraduate (junior-senior level) students majoring in biomedical engineering (20-30 students per class).
• Teaching this course required good understanding of designing, executing, and analyzing experiments related to biomechanics and bioinstrumentation. This course required extensive use of AutoCAD and LabVIEW.
• Taught lab section independently that involved designing, constructing, and/or improving the existing designs of a breathalyzer, a simple respiration monitor utilizing thermistor, photopleth heart rate monitor, and hemodialysis cartridge. The students were required to use AutoCAD to design their products and acquire data using LabVIEW to test and validate their products. Once the students finished designing and testing, some products like hemodialysis cartridge were 3D printed.

Teaching Assistant, Course: Engineering Materials, Properties, and Processing , Syracuse University (Fall 2011)

• This class involved teaching undergraduate (junior level) students majoring in engineering (130-180 students per class).
• Teaching this course required good understanding of the relationships between processing, structure, properties, and performance of materials.
• Taught recitations, graded homework and exams, and opened office hours to help students.

Grants:

• Research Fund for International Young Scientists from National Natural Science Foundation of China (NSFC), titled, "Systematic Investigation of Metal-Cell Interactions of Mg Alloys for Bone Regeneration and Bone Tumor Therapy" (Grant No. 52250410340) in 2022 (start-end date: 1/1/2023-12/31/2024).

Awards:

• Top Papers Award (优秀论文奖), Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, CAS (中国科学院深圳先进技术研究院生物医药与技术研究所), 2022
• Research Project Award (科研项目奖), Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, CAS (中国科学院深圳先进技术研究院生物医药与技术研究所), 2022
• Outstanding Employee (优秀员工), Shenzhen Institute of Advanced Technology, CAS (中国科学院深圳先进技术研究院), 2022
• 2nd place in Stevenson Biomaterials Research Poster Session, Syracuse Biomaterials Institute, 2016

Phi Beta Delta, Honor Society for International Scholars

• Member of Alpha Sigma Chapter starting April 2016

1. J Kim, JL Gilbert. Cytotoxic Effect of Galvanically Coupled Magnesium-Titanium Particles. Acta Biomater. 30, 368-377 (2016). DOI: 10.1016/j.actbio.2015.11.030

2. J Kim, JL Gilbert. The Effect of Cell Density, Proximity, and Time on the Cytotoxicity of Mg and Galvanically Coupled Mg-Ti Particles In Vitro. J. Biomed. Mater. Res. A 106, 1428-1439 (2018). DOI: 10.1002/jbm.a.36334

3. J Kim, JL Gilbert. In Vitro Cytotoxicity of Galvanically Coupled Magnesium-Titanium Particles on Human Osteosarcoma SAOS2 Cells: A Potential Cancer Therapy. J. Biomed. Mater. Res. B Appl. Biomater. 107, 178-189 (2018). DOI: 10.1002/jbm.b.34109

4. ES Ouellette, S Mali, J Kim, JL Gilbert. Design, Material, and Seating Load Effects on In Vitro Corrosion Performance of Modular Head-Neck Tapers. J. Arthroplasty 34, 991-1002 (2019). DOI: 10.1016/j.arth.2019.01.043

5. T Luechtefeld, N Lin, J Kim, CJ Paller, J Bressler. TET1 Survival Model Molecular Mediation Experiments in Glioma. Cancer Res. 79, 4255 (2019). DOI: 10.1158/1538-7445.AM2019-4255

6. J Kim, D Ren, JL Gilbert. Cytotoxic Effect of Galvanically Coupled Magnesium-Titanium Particles on Escherichia Coli. J. Biomed. Mater. Res. B Appl. Biomater. 109, 2162-2173 (2021). DOI: 10.1002/jbm.b.34864

7. K Deng, P Du, K Liu, X Tao, J Harati, JW Jhang, J Kim, PY Wang. Programming Colloidal Self-Assembled Patterns (cSAPs) into Thermo-Responsible Hybrid Surfaces for Controlling Human Stem Cells and Macrophages. ACS Appl. Mater. Interface. 13, 18563-18580 (2021). DOI: 10.1021/acsami.1c02969

8. M Enkhbat, YC Liu, J Kim, Y Xu, Z Yin, TM Liu, CX Deng, C Zou, X Xie, X Li, PY Wang. Expansion of Rare Cancer Cells into Tumoroids for Therapeutic Regimen and Cancer Therapy. Adv. Ther. 4, 2100017 (2021). DOI:  10.1002/adtp.202100017

9. J Kim, H Pan. Effects of Magnesium Alloy Corrosion on Biological Response- Perspectives of Metal-Cell Interaction. Prog. Mater. Sci. 133, 101039 (2022). DOI:  10.1016/j.pmatsci.2022.101039 

10. H Zhang, Y Cui, X Zhou, J Kim, H Li, S Li, H Yang, K Su, C Liu, P Tian, X Li, L Li, D Wang, L Zhao, J Wang, X Cui, B Li, H Pan. Biological Fixation of Bioactive Bone Cement in Vertebroplasty: The First Clinical Investigation of Borosilicate Glass (BSG) Reinforced PMMA Bone Cement. ACS Appl. Mater. Interface. 14, 51711-51727 (2022). DOI:  10.1021/acsami.2c15250 

11. S Li, L Zhang, C Liu, J Kim, K Su, T Chen, L Zhao, X Lu, H Zhang, Y Cui, X Cui, F Yuan, H Pan. Spontaneous Immunomodulation and Regulation of Angiogenesis and Osteogenesis by Sr/Cu-Borosilicate Glass (BSG) Bone Cement to Repair Critical Bone Defects. Bioact. Mater. 23, 101-117 (2023). DOI: 10.1016/j.bioactmat.2022.10.021 

12.  C Liu, X Cui, Y Du, X Wang, J Kim, S Li, L Zhang, X Zhao, L Zhao, P Tian, H Zhang, K Su, X Li, H Pan.  Unusual Surface Coagulation Activation Patterns of Crystalline and Amorphous Silicate-Based Biominerals. Adv. Healthc. Mater. 12, 2300039 (2023). DOI: 10.1002/adhm.202300039

1. Dr. Jeremy L Gilbert, Ph.D., FBSE, FAIMBE

Professor of Bioengineering

Clemson University

Address: 68 President’s Street, Charleston, SC 29425

Phone Number: 843-876-2235

E-Mail:  jlgilbe@clemson.edu

• Dr. Gilbert was my PhD advisor from Syracuse University. I also worked for him as an undergraduate research assistant and did my senior thesis, which was required for my BS degree.

2. Dr. Haobo Pan, Ph.D.

Chair Professor and Vice Director

Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Address: 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, Guangdong Province, China 518055

E-Mail: hb.pan@siat.ac.cn

• Dr. Pan is currently my supervisor at SIAT, CAS. I am a research member of his lab, where I work independently to do my own research projects and write grants. I also supervise and guide some of his graduate students and peer-review manuscripts.

3. Dr. Ping Du, Ph.D.

Assistant Professor,

Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Address: 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, Guangdong Province, China 518055

E-Mail: ping.du@siat.ac.cn

• Dr. Du supervised and guided me during my postdoc under Dr. Pan's lab. She taught me some important skills, such as western blot and qPCR. She is also one of the few members who can speak English, so she helped me with certain documents and reports that needed to be written in Chinese.

Teaching Assistant, Course: Biomaterials and Medical Devices, Syracuse University (Spring 2016 and Spring 2012)

• This class included undergraduate and graduate students majoring in biomedical engineering and biotechnology (60-80 students per class).
• Teaching this course required a good understanding of biomaterials used in medical devices and implants, biological systems involved with medical devices, and the design and performance of biomaterials-based medical devices.

Lab Instructor, Course: Quantitative Physiology , Syracuse University (Spring 2013)

• This class involved teaching undergraduate (junior-senior level) students majoring in biomedical engineering (20-30 students per class).
• Teaching this course required a good understanding of mammalian physiology from an engineering perspective, where each of the major systems of the body is addressed with an emphasis on electrical, mechanical, and thermodynamic principles. The lab section had to be taught independently and required extensive use of data acquisition software LabVIEW and MATLAB, as well as animal handling and dissection (e.g., frogs, worms, squid, rats).
• Some examples of lab course involved dissecting a frog to retrieve a leg muscle and then stimulating the sciatic nerve to show how the nerve activates the gastrocnemius muscle. MATLAB was used to model Windkessel model to study the fluid behavior in the cardiovascular system in different cardiac conditions (e.g., arrythmia, exercise, obesity, etc.). This lab also involved handling live rats to measure its frequency and tidal volume of respiration when various mixtures of respiratory gases were delivered.

Lab Instructor, Course: Bioengineering Laboratory , Syracuse University (Fall 2012)

• This class involved teaching undergraduate (junior-senior level) students majoring in biomedical engineering (20-30 students per class).
• Teaching this course required good understanding of designing, executing, and analyzing experiments related to biomechanics and bioinstrumentation. This course required extensive use of AutoCAD and LabVIEW.
• Taught lab section independently that involved designing, constructing, and/or improving the existing designs of a breathalyzer, a simple respiration monitor utilizing thermistor, photopleth heart rate monitor, and hemodialysis cartridge. The students were required to use AutoCAD to design their products and acquire data using LabVIEW to test and validate their products. Once the students finished designing and testing, some products like hemodialysis cartridge were 3D printed.

Teaching Assistant, Course: Engineering Materials, Properties, and Processing , Syracuse University (Fall 2011)

• This class involved teaching undergraduate (junior level) students majoring in engineering (130-180 students per class).
• Teaching this course required good understanding of the relationships between processing, structure, properties, and performance of materials.
• Taught recitations, graded homework and exams, and opened office hours to help students.

Grants:

• Research Fund for International Young Scientists from National Natural Science Foundation of China (NSFC), titled, "Systematic Investigation of Metal-Cell Interactions of Mg Alloys for Bone Regeneration and Bone Tumor Therapy" (Grant No. 52250410340) in 2022 (start-end date: 1/1/2023-12/31/2024).

Awards:

• Top Papers Award (优秀论文奖), Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, CAS (中国科学院深圳先进技术研究院生物医药与技术研究所), 2022
• Research Project Award (科研项目奖), Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, CAS (中国科学院深圳先进技术研究院生物医药与技术研究所), 2022
• Outstanding Employee (优秀员工), Shenzhen Institute of Advanced Technology, CAS (中国科学院深圳先进技术研究院), 2022
• 2nd place in Stevenson Biomaterials Research Poster Session, Syracuse Biomaterials Institute, 2016

Phi Beta Delta, Honor Society for International Scholars

• Member of Alpha Sigma Chapter starting April 2016

1. J Kim, JL Gilbert. Cytotoxic Effect of Galvanically Coupled Magnesium-Titanium Particles. Acta Biomater. 30, 368-377 (2016). DOI: 10.1016/j.actbio.2015.11.030

2. J Kim, JL Gilbert. The Effect of Cell Density, Proximity, and Time on the Cytotoxicity of Mg and Galvanically Coupled Mg-Ti Particles In Vitro. J. Biomed. Mater. Res. A 106, 1428-1439 (2018). DOI: 10.1002/jbm.a.36334

3. J Kim, JL Gilbert. In Vitro Cytotoxicity of Galvanically Coupled Magnesium-Titanium Particles on Human Osteosarcoma SAOS2 Cells: A Potential Cancer Therapy. J. Biomed. Mater. Res. B Appl. Biomater. 107, 178-189 (2018). DOI: 10.1002/jbm.b.34109

4. ES Ouellette, S Mali, J Kim, JL Gilbert. Design, Material, and Seating Load Effects on In Vitro Corrosion Performance of Modular Head-Neck Tapers. J. Arthroplasty 34, 991-1002 (2019). DOI: 10.1016/j.arth.2019.01.043

5. T Luechtefeld, N Lin, J Kim, CJ Paller, J Bressler. TET1 Survival Model Molecular Mediation Experiments in Glioma. Cancer Res. 79, 4255 (2019). DOI: 10.1158/1538-7445.AM2019-4255

6. J Kim, D Ren, JL Gilbert. Cytotoxic Effect of Galvanically Coupled Magnesium-Titanium Particles on Escherichia Coli. J. Biomed. Mater. Res. B Appl. Biomater. 109, 2162-2173 (2021). DOI: 10.1002/jbm.b.34864

7. K Deng, P Du, K Liu, X Tao, J Harati, JW Jhang, J Kim, PY Wang. Programming Colloidal Self-Assembled Patterns (cSAPs) into Thermo-Responsible Hybrid Surfaces for Controlling Human Stem Cells and Macrophages. ACS Appl. Mater. Interface. 13, 18563-18580 (2021). DOI: 10.1021/acsami.1c02969

8. M Enkhbat, YC Liu, J Kim, Y Xu, Z Yin, TM Liu, CX Deng, C Zou, X Xie, X Li, PY Wang. Expansion of Rare Cancer Cells into Tumoroids for Therapeutic Regimen and Cancer Therapy. Adv. Ther. 4, 2100017 (2021). DOI:  10.1002/adtp.202100017

9. J Kim, H Pan. Effects of Magnesium Alloy Corrosion on Biological Response- Perspectives of Metal-Cell Interaction. Prog. Mater. Sci. 133, 101039 (2022). DOI:  10.1016/j.pmatsci.2022.101039 

10. H Zhang, Y Cui, X Zhou, J Kim, H Li, S Li, H Yang, K Su, C Liu, P Tian, X Li, L Li, D Wang, L Zhao, J Wang, X Cui, B Li, H Pan. Biological Fixation of Bioactive Bone Cement in Vertebroplasty: The First Clinical Investigation of Borosilicate Glass (BSG) Reinforced PMMA Bone Cement. ACS Appl. Mater. Interface. 14, 51711-51727 (2022). DOI:  10.1021/acsami.2c15250 

11. S Li, L Zhang, C Liu, J Kim, K Su, T Chen, L Zhao, X Lu, H Zhang, Y Cui, X Cui, F Yuan, H Pan. Spontaneous Immunomodulation and Regulation of Angiogenesis and Osteogenesis by Sr/Cu-Borosilicate Glass (BSG) Bone Cement to Repair Critical Bone Defects. Bioact. Mater. 23, 101-117 (2023). DOI: 10.1016/j.bioactmat.2022.10.021 

12.  C Liu, X Cui, Y Du, X Wang, J Kim, S Li, L Zhang, X Zhao, L Zhao, P Tian, H Zhang, K Su, X Li, H Pan.  Unusual Surface Coagulation Activation Patterns of Crystalline and Amorphous Silicate-Based Biominerals. Adv. Healthc. Mater. 12, 2300039 (2023). DOI: 10.1002/adhm.202300039

1. Dr. Jeremy L Gilbert, Ph.D., FBSE, FAIMBE

Professor of Bioengineering

Clemson University

Address: 68 President’s Street, Charleston, SC 29425

Phone Number: 843-876-2235

E-Mail:  jlgilbe@clemson.edu

• Dr. Gilbert was my PhD advisor from Syracuse University. I also worked for him as an undergraduate research assistant and did my senior thesis, which was required for my BS degree.

2. Dr. Haobo Pan, Ph.D.

Chair Professor and Vice Director

Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Address: 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, Guangdong Province, China 518055

E-Mail: hb.pan@siat.ac.cn

• Dr. Pan is currently my supervisor at SIAT, CAS. I am a research member of his lab, where I work independently to do my own research projects and write grants. I also supervise and guide some of his graduate students and peer-review manuscripts.

3. Dr. Ping Du, Ph.D.

Assistant Professor,

Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Address: 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, Guangdong Province, China 518055

E-Mail: ping.du@siat.ac.cn

• Dr. Du supervised and guided me during my postdoc under Dr. Pan's lab. She taught me some important skills, such as western blot and qPCR. She is also one of the few members who can speak English, so she helped me with certain documents and reports that needed to be written in Chinese.