Yipin Zhao

I primarily specialize in both clinical and basic research on heart diseases, with a primary focus on myocardial remodeling in heart failure and mitochondrial function. Currently, my research is heavily concentrated on exploring the mechanisms related to mitochondrial copper metabolism and its association with cardiac hypertrophy. Additionally, I am keenly interested in bioinformatics and clinical database analysis. In recognition of my contributions, I was awarded the ACC-FIT title by the American College of Cardiology (ACC) in 2018.

No. 1 Fuwai Road, Zhengdong New District, Zhengzhou, Henan 451464, China.

• Knowing how to handle hazardous materials, operate equipment safely, and follow emergency procedures. Skillfully preparing biological samples, including collection, preservation, and processing. Mastering the use of microscopes to observe and analyze biological specimens.
• Have expertise in culturing cells in vitro. This includes maintaining cell lines, preparing culture media, and passaging cells. Understand the requirements for sterile technique and be able to prevent contamination of cell cultures.
• Capable of performing protein quantification, Western blotting, and enzyme assays. This involves understanding the principles of these techniques and being able to interpret the results. Be able to use specialized equipment such as spectrophotometers and fluorimeters for protein analysis.
• Accurately collect and record experimental data using appropriate methods and tools. This may include using software for data logging and instrument control. Be able to analyze data using statistical methods and software packages to draw meaningful conclusions from experiments.

• Designed and implemented studies investigating the predictive value of fibrinogen-to-albumin ratio in STEMI patients undergoing PCI (Heart Vessels, 2019).
• Led research on the association between fibrinogen-to-albumin ratio and coronary collateral circulation in stable coronary artery disease (Biomark Med, 2020).
• Spearheaded the study on D-dimer to Creatinine Ratio as a biomarker linked to Gensini Score in STEMI (Clin Appl Thromb Hemost, 2022).
• Introduced Gamma-Glutamyl Transpeptidase to Platelet Ratio as an inflammatory marker post-cardiac arrest (Mediators Inflamm, 2021).
• Contributed pivotally to the subgroup analysis examining Sitagliptin's impact on carotid intima-media thickness in type 2 diabetes and hyperuricemia patients (Ther Adv Chronic Dis, 2021).
• Co-authored studies establishing Blood Urea Nitrogen to Serum Albumin Ratio and MELD-XI score as prognostic tools in chronic heart failure (ESC Heart Fail, 2022; Front Cardiovasc Med, 2022).
• Conducted a systematic review and meta-analysis assessing the effects of β-hydroxy β-methylbutyrate on lean body mass in older adults (Eur Geriatr Med, 2021).
• Collaborated on studies exploring cuproptosis's role in pulmonary fibrosis (Front Immunol, 2022) and cardiac fibroblast differentiation under pressure overload (Oxid Med Cell Longev, 2022).
• Participated in research demonstrating Ghrelin's neuroprotective effects on cerebral microvascular leakage (Biochem Biophys Res Commun, 2021).

• American College of Cardiology Fellows in Training Member（ACC-FIT）
• Member of the Structural Heart Disease Branch of Henan Bioengineering Society

• Zhao Y, Yang J, Ji Y, Wang S, Wang T, Wang F, Tang J: Usefulness of fibrinogen-to-albumin ratio to predict no-reflow and short-term prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Heart Vessels 2019, 34:1600-1607.
• Zhao Y, Wang S, Yang J, Lin Z, Chen Q: Association of fibrinogen/albumin ratio and coronary collateral circulation in stable coronary artery disease patients. Biomark Med 2020, 14:1513-1520.
• Yang J, Zhao Y, Li Y, Tang J, Zhao Y: D-dimer to Creatinine Ratio: A Novel Biomarker Associated with Gensini Score in ST-Segment Elevation Myocardial Infarction Patients. Clin Appl Thromb Hemost 2022, 28:10760296221099938.
• Zhao Y, Lin Z, Ji Y, Wang H, Xiao L, Chen Q, Wu Z: Gamma-Glutamyl Transpeptidase to Platelet Ratio: A New Inflammatory Marker Associated with Outcomes after Cardiac Arrest. Mediators Inflamm 2021, 2021:5537966.
• Zhao Y, Wang H, Ke D, Deng W, Ji Y, Yang J, Lin Z, Li G, Xiao L, Tang J, Chen Q: Sitagliptin on carotid intima-media thickness in type 2 diabetes and hyperuricemia patients: a subgroup analysis of the PROLOGUE study. Ther Adv Chronic Dis 2021, 12:20406223211026993.
• Lin Z, Zhao Y, Xiao L, Qi C, Chen Q, Li Y: Blood urea nitrogen to serum albumin ratio as a new prognostic indicator in critical patients with chronic heart failure. ESC Heart Fail 2022, 9:1360-1369.
• Lin Z, Liu X, Xiao L, Li Y, Qi C, Song S, Zhao Y, Zou L: The MELD-XI score predicts 3-year mortality in patients with chronic heart failure. Front Cardiovasc Med 2022, 9:985503.
• Lin Z, Zhao Y, Chen Q: Effects of oral administration of β-hydroxy β-methylbutyrate on lean body mass in older adults: a systematic review and meta-analysis. Eur Geriatr Med 2021, 12:239-251.
• Li G, Peng L, Wu M, Zhao Y, Cheng Z, Li G: Appropriate level of cuproptosis may be involved in alleviating pulmonary fibrosis. Front Immunol 2022, 13:1039510.
• Wu CR, Yang QY, Chen QW, Li CQ, He WY, Zhao Y, Wang L: Ghrelin attenuate cerebral microvascular leakage by regulating inflammation and apoptosis potentially via a p38 MAPK-JNK dependent pathway. Biochem Biophys Res Commun 2021, 552:37-43.
• Li G, Qin Y, Cheng Z, Cheng X, Wang R, Luo X, Zhao Y, Zhang D, Li G: Gpx3 and Egr1 Are Involved in Regulating the Differentiation Fate of Cardiac Fibroblasts under Pressure Overload. Oxid Med Cell Longev 2022, 2022:3235250.

• Obtained the Chinese practicing physician qualification certificate in 2017.
• Passed the national attending physician examination in China in 2023.

In my leisure time, I am an avid enthusiast of cross-cultural exploration. Traveling and reading extensively have allowed me to delve into the histories, arts, and societal customs of diverse regions, enriching my life experiences and honing my intercultural communication skills. Beyond academics, I find solace and inspiration in music and photography, which serve as avenues for relaxation and creativity. Furthermore, I actively engage in outdoor activities such as hiking and cycling, fostering resilience, perseverance, and a fearless attitude towards challenges.